I think the fact they went to the trouble of casting Dr. Connors with (in my eyes) a fine actor and involving him twice in the film series, he will eventually become the Lizard. He too is one of my favorite villains and he's one of the older, classic Spider man bad guys.
The movies have been using mostly the old school spider man villains (pretty much the entire Sinister six is as classic as you can get). I think if they do bring Lizard in he should come along with Kraven the hunter, the two would be ideal opposing villains: a hunter and an animal.
I have a feeling the likes of Mysterio and Vulture will eventually pop up into Spidery's big silver screen universe.
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