That's why I do all the World and Guide missions before doing the Nano one(s). During the beta testings, I focused too much on getting the Nanos more than completing missions. During the sneak preview, I chose to complete all missions before going into doing any Nano mission.
Guides: I went with Mojo Jojo for a little while, then switched to Double D/Edd later during "beta". I stuck with Ben Tennyson during the preview. It does cost you, each time you change guides.
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